ANNE CHAOHuang, Yhu-CheringYhu-CheringHuangChang, Yao-LungYao-LungChangWang, Tzu-HaoTzu-HaoWangChang, Shuenn-DyhShuenn-DyhChangWu, Ting-ShuTing-ShuWuWu, Tsu-LanTsu-LanWuChao, An-ShineAn-ShineChao2018-09-102018-09-102013http://www.scopus.com/inward/record.url?eid=2-s2.0-84884592217&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/379707Objective: To determine the prevalence of preexisting antibodies against the pandemic 2009 Influenza A (H1N1) virus in pregnant women and to evaluate the seroprotection of the mothers and infants by a single injection of monovalent vaccine during the pandemic. Materials and Methods: Seropositivity rate of H1N1 among the nonvaccinated were compared with the vaccinated women. A single dose of vaccine, either nonadjuvanted AdimFlu-S or MF59-adjuvanted vaccine, was injected to the voluntarily vaccinated group. Maternal and cord blood sera were collected to evaluate the antibody response of the H1N1 virus. Seropositivity was defined as a hemagglutination inhibition titer to H1N1 (A/Taiwan/126/09) ?1:40. Results: A total of 210 healthy, singleton, pregnant women were enrolled between January 2010 and May 2010. Seropositivity (?1:40) of maternal hemagglutination inhibition was significantly higher in the vaccinated group (78%) than the nonvaccinated group (9.5%); 41.6% (20/48) of seropositive titers were >1:80. In nine vaccinated cases resulting in negative serum titers (<1:40), the prevalence of negative titer in the women received AdimFlu-S (14.8%, 4/31) was lower (p=0.025) than those received MF59-adjuvanted vaccine (50%, 5/10). Conclusions: Subclinical infection against H1N1 was low in Taiwanese pregnant women in the pandemic 2009. Seropositivity >75% could be achieved in the paired maternal and cord serum samples by a single injection of monovalent H1N1 vaccine. ? 2013.H1N1; Infant; Influenza A; Pregnancy; Vaccine[SDGs]SDG3adimflu s; influenza vaccine; unclassified drug; adult; antibody response; antibody titer; article; asymptomatic infection; controlled study; female; hemagglutination inhibition; human; influenza A (H1N1); Influenza virus A H1N1; maternal blood; normal human; pandemic influenza; pregnant woman; seroconversion; seroprevalence; umbilical cord blood; H1N1; infant; influenza A; pregnancy; vaccine; Adjuvants, Immunologic; Antibodies, Viral; Female; Hemagglutination Inhibition Tests; Humans; Infant; Infant, Newborn; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Influenza, Human; Maternal-Fetal Exchange; Mothers; Population Surveillance; Pregnancy; Prospective Studies; Seroepidemiologic Studies; Taiwanjournal article10.1016/j.tjog.2013.06.002