Lin, K.-Y.K.-Y.LinTsai, M.-L.M.-L.TsaiChien, I.-L.I.-L.ChienI-LUNG CHIEN2021-02-042021-02-042020https://www.scopus.com/inward/record.url?eid=2-s2.0-85086931378&partnerID=40&md5=a10862b7b67bf349a7758dbba6a7ea99https://scholars.lib.ntu.edu.tw/handle/123456789/546398This work mainly focus on providing an energy-efficient design scheme for the separation of ternary mixture containing diisopropyl ether, isopropanol and water. The residue curve maps of this mixture is very complex, including: three binary azeotropes, one ternary azeotrope, three distillation regions and liquid–liquid envelope. With the preference of not adding foreign component into this separation, a new energy-efficient design flowsheet is proposed in this paper making use of natural liquid–liquid separation in a decanter together with varying operating pressure to expand the operating distillation region for the respective column. This design flowsheet can further be heat-integrated to combine a condenser of one column with partial heat input of a reboiler of another column and also add a feed-effluent heat exchanger to preheat the feed of one column. By comparing the economic performance of the proposed design flowsheet with that of a design flowsheet published in a recent paper, significant savings in total annual cost of 42.9% and in annual operating cost of 48.1% can be realized by our proposed design flowsheet. © 2020 Elsevier B.V.Energy-saving scheme; Liquid–liquid separation; Multiple azeotropes; Pressure-swing distillation; Process design; Ternary separation[SDGs]SDG7[SDGs]SDG12Azeotropes; Distillation; Distilleries; Effluents; Energy efficiency; Flowcharting; Liquids; Annual operating costs; Diisopropyl ether; Economic performance; Energy efficient; Energy-efficient design; Liquid separation; Operating pressure; Residue curve maps; Distillation columns; Azeotropes; Design; Distillation; Effluents; Feeds; Heat; Liquids; Separationjournal article10.1016/j.seppur.2020.1172922-s2.0-85086931378WOS:000564725900002