YUNG-LI YANGHsiao C.-C.Chen H.-Y.Lin K.-H.SHIANN-TANG JOUChen J.-S.Chang T.-K.Sheen J.-M.SUNG-LIANG YUMENG-YAO LUCheng C.-N.Wu K.-H.Wang S.-C.Wang J.-D.HSIU-HAO CHANGLin S.-R.SHU-WHA LINLin D.-T.2020-12-182020-12-1820121545-5009https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863353013&doi=10.1002%2fpbc.24021&partnerID=40&md5=a3d10aa8b3d7f0dbf4bc48a261c3ee79https://scholars.lib.ntu.edu.tw/handle/123456789/527846Background: The absence of biallelic TCRγ deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL). This study aimed to investigate its prognostic value in Taiwanese patients with T-cell ALL. Procedure: Forty-five children with T-cell ALL were enrolled from six medical centers in Taiwan. Quantitative DNA polymerase chain reaction (Q-PCR) was performed to check the status of TCRγ deletion. The threshold for homozygous deletions by Q-PCR was defined as a fold-change <0.35. Results: ABD was found in 20 patients [20:45] who had higher incidences of induction failure than those without ABD (P=0.03; hazard ratio [HR]=8.13; 95% confidence interval [95% CI]=1.23-53.77) after multivariate regression analysis. Patents with ABD also had inferior EFS and OS (P=0.071 and 0.0196, respectively). Multivariate Cox analysis indicated that the association between ABD and overall survival was independent of age and leukocyte count on presentation (P=0.036; HR=4.25; 95% CI=1.10-16.42). Conclusions: The absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T-cell ALL in Taiwan. Providing patients with T-cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. ? 2011 Wiley Periodicals, Inc.[SDGs]SDG3dexamethasone; DNA polymerase; prednisolone; T lymphocyte receptor gamma chain; acute lymphoblastic leukemia; age; article; cancer chemotherapy; cancer incidence; cancer patient; cancer survival; child; childhood leukemia; clinical article; controlled study; drug dose reduction; female; gene deletion; homozygous deletion; human; immunophenotyping; leukemia remission; leukocyte count; male; outcome assessment; overall survival; polymerase chain reaction; prediction; priority journal; prognosis; quantitative analysis; school child; T cell leukemia; Taiwan; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Gene Deletion; Genes, T-Cell Receptor gamma; Humans; Immunophenotyping; Induction Chemotherapy; Kaplan-Meier Estimate; Polymerase Chain Reaction; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcomejournal article10.1002/pbc.24021221801812-s2.0-84863353013