Ho, Tsung-ChuanTsung-ChuanHoYeh, Shu-IShu-IYehSHOW-LI CHENChu, Ting-WenTing-WenChuTsao, Yeou-PingYeou-PingTsao2023-12-192023-12-192022-02-221471-2415https://scholars.lib.ntu.edu.tw/handle/123456789/637981Pigment epithelial-derived factor (PEDF), a 50 kDa secreted glycoprotein, exhibits distinct effects on a range of cell types. PEDF has been shown to inhibit vascular endothelial growth factor (VEGF)-mediated angiogenesis and widely accepted as a promising agent for treatment eye diseases related to neovascularization. A pool of short peptide fragments derived from PEDF reportedly manifests angioinhibitory activity. This study aims to determine the minimal PEDF fragment which can exert the anti-VEGF effect.enApoptosis; Corneal neovascularization; Peptide; Pigment epithelial-derived factor; Vascular endothelial growth factor[SDGs]SDG3journal article10.1186/s12886-022-02295-0351935482-s2.0-85125153880https://api.elsevier.com/content/abstract/scopus_id/85125153880