王大銘2006-07-252018-06-282006-07-252018-06-282002http://ntur.lib.ntu.edu.tw//handle/246246/9307本研究採用牛血清蛋白(BSA)與蝕刻 性polycarbonate 微孔膜，進行恆壓過濾， 藉以探討蛋白質過濾的結垢現象。以掃瞄 式電子顯微鏡（SEM ）分析結垢薄膜的表 面結構，發現濾速衰減的主因是由於蛋白 質聚集體堆積於膜面成一結垢層。過濾前 期阻力增加的原因是聚集體的堆積，後期 則是由聚集體的壓縮來主導過濾阻力的增 加。研究中量測平均孔隙度及過濾比阻隨 時間的變化，並分析其間的關聯性，發現 以Voigt 模式來描述孔隙度隨過濾時間的 變化，而以Kozeny 方程式來描述過濾比阻 與孔隙度間之關係，十分吻合實驗所得之 結果。再將壓縮模式併入孔洞阻塞與粒子 堆積的結合模式中，可準確描述結垢薄膜的阻力成長過程。In this present work, to clarify the mechanism of protein fouling, microfiltration experiments were performed with bovine serum albumin (BSA) and track-etched poly-carbonate membranes. On the basis of the SEM analysis on the fouling layers and the in-situ measurement of the thickness of protein deposits, it was found that the deposition rate of BSA aggregates governed the growth of filtration resistance in the initial period. On the other hand, in the late period, the dominant mechanism was the compression of the deposited layer. To develop a suitable model for the resistance growth due to compression, the time dependence of cake porosity and the relationship between specific cake resistance and cake porosity were determined. The results suggest that the time dependence of cake porosity can be described by the Voigt model, and the relationship between specific cake resistance and cake porosity can be described by the Kozeny equation. By incorporating the compression model into the combined model of pore-blockage and cake filtration, the resistance growth during microfiltration can be well described.application/pdf301271 bytesapplication/pdfzh-TW國立臺灣大學化學工程學系暨研究所微過濾結垢現象蛋白質孔隙度壓縮模式microfiltrationfoulingproteinporositycompression modelreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/9307/1/902214E002026.pdf