RUOH-FANG YENHung R.-L.Pan M.-H.Wang Y.-H.Huang K.-M.Lui L.T.Kao C.-H.2020-09-232020-09-2320030008-543Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/514539BACKGROUND. It is known that 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is effective in the early detection of residual/recurrent nasopharyngeal carcinomas (NPC). To compare FDG-PET with the conventional magnetic resonance imaging (MRI) for the detection of residual/recurrent NPC, the authors studied 67 follow-up cases of patients with NPC using both FDG-PET and MRI. METHODS. From February 1997 to February 2001, 67 NPC patients (14 women, 53 men; age range, 16-67 years; mean age, 46.6 ± 12.5 years) were recruited. Both FDG-PET and MRI of the head and neck area for each patient were performed at least 4 months (duration range, 4-70 months; mean, 14 ± 13.5 months) after radiotherapy or radiotherapy with concurrent chemotherapy. The final diagnosis was confirmed by biopsy or clinical follow-up for at least 6 months. RESULTS. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of FDG-PET images were 100%, 93.4%, 95.5%, 87.5%, and 100%, respectively. In contrast, the sensitivity, specificity, accuracy, PPV, and NPV of the MRI scans were 61.9%, 43.5%, 49.3%, 33.3%, and 70.0%, respectively. CONCLUSIONS. The results of the current study suggest that FDG-PET is much more effective than MRI in detecting residual/recurrent NPC. ? 2003 American Cancer Society.[SDGs]SDG3fluorodeoxyglucose f 18; adolescent; adult; aged; article; cancer chemotherapy; cancer diagnosis; cancer patient; cancer radiotherapy; clinical trial; controlled clinical trial; controlled study; diagnostic accuracy; female; follow up; head and neck cancer; human; intermethod comparison; major clinical study; male; nasopharynx carcinoma; nuclear magnetic resonance imaging; positron emission tomography; prediction; priority journal; tumor biopsy; Adolescent; Adult; Aged; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Neoplasm, Residual; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computedjournal article10.1002/cncr.11519128723462-s2.0-0038007429