MIN-HSIUNG PANYang, G.G.YangLi, S.S.LiLi, M.-Y.M.-Y.LiTsai, M.-L.M.-L.TsaiWu, J.-C.J.-C.WuBadmaev, V.V.BadmaevHo, C.-T.C.-T.HoLai, C.-S.C.-S.Lai2018-09-102018-09-102017http://www.scopus.com/inward/record.url?eid=2-s2.0-85026443285&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/402423Scope: SlimTrym? is a formulated product composed of citrus polymethoxyflavones (PMFs), green tea extract, and lychee extract. We investigated the effect of dietary SlimTrym? on diet-induced obesity and associated non-alcoholic fatty liver disease (NAFLD) in mice. Methods and results: Male C57BL/6 mice were fed a normal diet (ND), high fat diet (HFD) or HFD containing 0.1% or 0.5% SlimTrym? for 16 weeks. Dietary SlimTrym? significantly reduced weight gain and relative perigonadal, retroperitoneal, mesenteric fat weight as well as the size of adipocyte in HFD-fed mice. SlimTrym? supplementation also effectively diminished hepatic steatosis and the serum levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), triacylglycerol (TG), and total cholesterol (TCHO). Down-regulation of peroxisome proliferator-activated receptor (PPAR)γ, sterol regulatory element-binding protein (SREBP)-1, and the activation of AMP-activated protein kinase (AMPK) signaling by SlimTrym? in both adipose tissue and liver may be responsible for the observed anti-obesity effects. Conclusion: SlimTrym? supplementation potentially diminished diet-induced obesity and hepatic steatosis via regulating AMPK signaling and molecules involved in lipid metabolism. ? 2017 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimGreen tea polyphenol; Hepatic steatosis; High-fat diet; Lychee; Polymethoxyflavones[SDGs]SDG3antiobesity agent; biological marker; flavone derivative; plant extract; polyphenol; adipogenesis; analysis; animal; blood; C57BL mouse; Camellia sinensis; chemistry; Citrus; comparative study; dietary supplement; ethnopharmacology; food handling; fruit; lipid diet; lychee; male; metabolism; methylation; nonalcoholic fatty liver; obesity; oxidation reduction reaction; plant leaf; Taiwan; Adipogenesis; Animals; Anti-Obesity Agents; Biomarkers; Camellia sinensis; Citrus; Diet, High-Fat; Dietary Supplements; Ethnopharmacology; Flavones; Food Handling; Fruit; Litchi; Male; Methylation; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction; Plant Extracts; Plant Leaves; Polyphenols; Taiwanjournal article10.1002/mnfr.201601104