Hung T.-M.Hsiao C.-C.Lin C.-W.PO-HUANG LEE2021-04-292021-04-2920202076-0817https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083832687&doi=10.3390%2fpathogens9030225&partnerID=40&md5=9f271a3c489084a50ac6240b31e46b6bhttps://scholars.lib.ntu.edu.tw/handle/123456789/558356The lysosomal degradation pathway, or autophagy, plays a fundamental role in cellular, tissue, and organismal homeostasis. A correlation between dysregulated autophagy and liver fibrosis (including end-stage disease, cirrhosis) is well-established. However, both the up and downregulation of autophagy have been implicated in fibrogenesis. For example, the inhibition of autophagy in hepatocytes and macrophages can enhance liver fibrosis, whereas autophagic activity in hepatic stellate cells and reactive ductular cells is permissive towards fibrogenesis. In this review, the contributions of specific cell types to liver fibrosis as well as the mechanisms underlying the effects of autophagy are summarized. In view of the functional effects of multiple cell types on the complex process of hepatic fibrogenesis, integrated approaches that consider the role of autophagy in each liver cell type should be a focus of future research. ? 2020 by the authors. Licensee MDPI, Basel, Switzerland.Autophagy; Cirrhosis; Fibrosis; Liver cell[SDGs]SDG33 methyladenine; alpha smooth muscle actin; autophagy related protein 12; autophagy related protein 5; autophagy related protein 8 family; carbon tetrachloride; caveolin 1; F actin; interleukin 1alpha; interleukin 1beta; nitric oxide; phosphatidylethanolamine; phosphatidylinositol 3 kinase; sequestosome 1; serine threonine protein kinase ULK1; transcription factor Nrf2; transforming growth factor beta; angiogenesis; autolysosome; autophagosome; autophagy (cellular); cell differentiation; cells by body anatomy; cholangiocyte; down regulation; fibrogenesis; gene knockout; hepatic stellate cell; homeostasis; human; immune response; immunohistochemistry; inflammation; liver cell; liver cirrhosis; liver fibrosis; liver protection; macrophage; mesenchyme cell; nonhuman; Reviewreview10.3390/pathogens90302252-s2.0-85083832687