2016-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/680997摘要：“搔癢生樂受，無癢更安樂（龍樹菩薩）。”我們為何會去抓癢？癢可以定義為一種不愉快的感覺會引發去抓癢的欲望。在日常生活經驗中抓癢可以止癢且得到快感。然而，仍有數以百萬的人深受無法根治的癢所苦。癢與止癢的關係是我們身體與大腦的秘密之一。迄今我們對於止癢及止癢得到的快感內在的分子與神經生物機制仍然所知不多。有趣的是這兩件事顯然是一體的兩面。由於相似的腦區可能牽涉了止癢的快感與得到酬賞，值得進一步去探究其內在神經生物機制。植基於我們台大與中研院團隊的長期合作與豐碩的成果，我們團隊計畫利用結合了化學遺傳學與光遺傳學兩項特質的化學-光遺傳學進一步合作去探討止癢與決策所牽涉的酬賞迴路與機制。<br> Abstract: “There is pleasure when an itch is scratched, but to be without an itch is more pleasurable still (by Buddhist philosopher Nagarjuna)”. Why do we scratch an itch? Itch is defined as an unpleasant sensation that evokes a desire to scratch. Our daily experience tells that scratching relieves itch and is pleasurable. However, this may be not the case for the millions of people who suffer from intractable itch. The itch-scratch relationship is one of the mysteries in our bodies and brain. Up to date, little is known about the molecular and neurobiological basis of itch-relief and the following pleasure. Interestingly, itch and itch relief-induced pleasure appear to be two sides of the same coin. Giving the factors that similar brain circuits and areas might be involved in the processes of reward and pain relief, it is of great interest to investing neurobiological basis of rewarding circuitry involved in itch and itch relief-induced pleasure. Based on our long-term collaboration between NTU and Academia Sinica and our fruitful outcomes, we would like to move one step further to explore the rewarding circuitry involved in itch relief-induced pleasure and decision making from a chemo-optogenetic, a combination of both chemogenetics and optogenetics, approach.癢止癢愉悅決策神經迴路酬賞化學-光遺傳學itchitch reliefpleasuredecision makingneural circuitrewardchemo-optogenetics