Lee, C.-H.C.-H.LeeCheng, S.-H.S.-H.ChengHuang, I.-P.I.-P.HuangSouris, J.S.J.S.SourisYang, C.-S.C.-S.YangCHUNG-YUAN MOULo, L.-W.L.-W.Lo2018-09-102018-09-102010http://www.scopus.com/inward/record.url?eid=2-s2.0-78249241778&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/356387Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. ? 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Antitumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous silica[SDGs]SDG3Anti-tumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous Silica; Cell death; Mesoporous materials; Nanoparticles; Silica; antineoplastic agent; drug carrier; nanoparticle; silicon dioxide; article; cell line; chemistry; confocal microscopy; human; infrared spectroscopy; pH; spectrofluorometry; transmission electron microscopy; Antineoplastic Agents; Cell Line; Drug Carriers; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles; Silicon Dioxide; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infraredjournal article10.1002/anie.2010026392-s2.0-78249241778WOS:000284009100030