Chou, Shih HuaShih HuaChouChen, Yen JuYen JuChenLiao, Chien PoChien PoLiaoCHUN-LIANG PAN2022-03-022022-03-022022-01-0101680102https://scholars.lib.ntu.edu.tw/handle/123456789/595884Physiological stress triggers aversive learning that profoundly alters animal behavior. Systemic mitochondrial disruption induces avoidance of C. elegans to non-pathogenic food bacteria. Mutations in cat-2 and dat-1, which control dopamine synthesis and reuptake, respectively, impair this learned bacterial avoidance, suggesting that dopaminergic modulation is essential. Cell-specific rescue experiments indicate that dopamine likely acts from the CEP and ADE neurons to regulate learned bacterial avoidance. We find that mutations in multiple dopamine receptor genes, including dop-1, dop-2 and dop-3, reduced learned bacterial avoidance. Our work reveals a role for dopamine signaling in C. elegans learned avoidance behavior induced by mitochondrial stress.enAversive learning | Avoidance behavior | C. elegans | Dopamine | Mitochondria | Neural circuit | Stress[SDGs]SDG3journal article10.1016/j.neures.2022.01.005350744442-s2.0-85123691588https://api.elsevier.com/content/abstract/scopus_id/85123691588https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123691588&doi=10.1016%2fj.neures.2022.01.005&partnerID=40&md5=8621a2204f5ef8376aff08a59aeae74c