Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics

Huang, Chung-ErChung-ErHuangMa, Gwo-ChinGwo-ChinMaJou, Hei-JenHei-JenJouLin, Wen-HsiangWen-HsiangLinLee, Dong-JayDong-JayLeeLin, Yi-ShingYi-ShingLinGinsberg, Norman ANorman AGinsbergHSIN-FU CHENChang, Frank Mau-ChungFrank Mau-ChungChangMING CHEN2022-12-142022-12-1420171755-8166https://scholars.lib.ntu.edu.tw/handle/123456789/626406Noninvasive prenatal testing (NIPT) based on cell-free DNA in maternal circulation has been accepted worldwide by the clinical community since 2011 but limitations, such as maternal malignancy and fetoplacental mosaicism, preclude its full replacement of invasive prenatal diagnosis. We present a novel silicon-based nanostructured microfluidics platform named as "Cell Reveal™" to demonstrate the feasibility of capturing circulating fetal nucleated red blood cells (fnRBC) and extravillous cytotrophoblasts (EVT) for cell-based noninvasive prenatal diagnosis (cbNIPD).enAneuploidy; EVT; Fish; NGS; NIPT; aCGH; cbNIPD; fnRBC[SDGs]SDG3Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidicsjournal article10.1186/s13039-017-0343-3292133312-s2.0-85036577700WOS:000417063600001https://api.elsevier.com/content/abstract/scopus_id/85036577700