陳建仁2006-07-252018-06-292006-07-252018-06-292002-07-31http://ntur.lib.ntu.edu.tw//handle/246246/4683In order to compare the chromosomal imbalances between arsenic-induced and non-arsenic-induced TCC, we analyzed 24 arsenic-induced and 25 non-arsenic-induced TCC by comparative genomic hybridization. More arsenic-induced TCCs had at least one chromosomal imbalance (100%) than non-arsenic- induced TCCs (70%). The number of chromosomal imbalances (mean + standard error) was also significantly higher in the arsenic- induced TCCs (5.7+0.6) than non-arsenic-induced TCCs (2.9+0.5). Arsenic exposure is significantly associated with an increased number of chromosomal imbalances after adjustment for cigarette smoking and grade and stage of TCCs in the multiple linear regression analysis. We also found a significantly higher frequency of chromosome gains at 1p12-13, 3q24-25, 4q12-13, 7q112 and 8q22 in arsenic-induced TCCs than in non-arsenic-induced ones. In addition, the frequency of chromosome losses in 16p132-p133 and 17p13 was also significantly higher in arsenic-induced TCCs than non-arsenic-induced ones.application/pdf157748 bytesapplication/pdfzh-TW國立臺灣大學公共衛生學院流行病學研究所reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/4683/1/902314B002179.pdf