Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model

Chen, Yun-TiYun-TiChenChang, Yu-HsiuYu-HsiuChangPathak, NikhilNikhilPathakTzou, Shey-CherngShey-CherngTzouLuo, Yong-ChunYong-ChunLuoHsu, Yen-ChaoYen-ChaoHsuLi, Tian-NengTian-NengLiLee, Jung-YuJung-YuLeeChen, Yi-CyunYi-CyunChenHuang, Yu-WeiYu-WeiHuangYang, Hsin-JuHsin-JuYangHsu, Nung-YuNung-YuHsuTsai, Hui-PingHui-PingTsaiChang, Tein-YaoTein-YaoChangHsu, Shu-ChenShu-ChenHsuLiu, Ping-ChengPing-ChengLiuChin, Yuan-FanYuan-FanChinLin, Wen-ChinWen-ChinLinYang, Chuen-MiChuen-MiYangWu, Hsueh-LingHsueh-LingWuLee, Chia-YingChia-YingLeeHsu, Hui-LingHui-LingHsuLiu, Yi-ChunYi-ChunLiuChu, Jhih-WeiJhih-WeiChuWang, Lily Hui-ChingLily Hui-ChingWangJANN-YUAN WANGHuang, Chih-HengChih-HengHuangLin, Chi-HungChi-HungLinHsieh, Po-ShiuanPo-ShiuanHsiehWu Lee, Yan-HwaYan-HwaWu LeeHung, Yi-JenYi-JenHungYang, Jinn-MoonJinn-MoonYang2023-09-052023-09-0520221664-3224https://scholars.lib.ntu.edu.tw/handle/123456789/635055Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of the right therapeutic targets and the right drugs for combating the disease.enSARS-CoV-2; drug repurposing; inflammation; methotrexate; multi-target drugsMethotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster modeljournal article10.3389/fimmu.2022.1080897366184122-s2.0-85145501009https://api.elsevier.com/content/abstract/scopus_id/85145501009