Su W.W.-Y.Su C.-W.Chang D.-C.Chuang S.-L.Chen S.L.-S.Hsu C.-Y.Yen A.M.-F.Chiu S.Y.-H.Fann J.C.-Y.Lee Y.-H.Jeng Y.-C.YI-CHIA LEEHAN-MO CHIUChen, Tony Hsiu HsiTony Hsiu HsiChenCHENG-PING WANGChen M.-K.2020-11-032020-11-0320191043-3074https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060137972&doi=10.1002%2fhed.25579&partnerID=40&md5=9f7c4fd638323859a11e77ab2e28a986https://scholars.lib.ntu.edu.tw/handle/123456789/520267Background: To elucidate the impact of varying anatomic sites on advanced stage of and death from oral cancer. Methods: A total of 27 717 oral cancers mainly from a population-based visual inspection program in Taiwan from 2004 to 2009 was followed until the end of 2012. Results: Using lip cancer as reference, the odds ratios (95% confidence interval [CI]) of advanced stage of cancer were 2.20 (1.92-2.51) for tongue, 2.60 (2.28-2.97) for buccal, 2.68 (2.20-3.28) for floor of mouth, 2.96 (2.52-3.47) for hard palate, 6.04 (5.17-7.05) for gingiva, and 10.83 (9.20-12.74) for oropharynx. The estimated hazard ratios (95% CI) for oral cancer death increased from 1.48 (1.31-1.67) in buccal, 1.61 (1.43-1.82) in tongue, 1.68 (1.41-1.99) in floor of mouth, 1.79 (1.57-2.05) in gingiva, 1.97 (1.71-2.26) in hard palate, and 2.15 (1.89-2.45) in oropharynx. Conclusion: Different anatomic sites had variations in advanced stage of and death from oral cancer and need vigilant surveillance. ? 2019 Wiley Periodicals, Inc.[SDGs]SDG3adult; advanced cancer; age; anatomical concepts; Article; betel quid; cancer staging; cancer survival; cigarette smoking; cohort analysis; female; follow up; gingiva; hard palate; human; lip cancer; major clinical study; male; middle aged; mouth cancer; oropharynx; oropharynx cancer; priority journal; prospective study; sex difference; Taiwan; tongue cancer; adverse event; aged; alcoholism; cause of death; cheek; comparative study; complication; confidence interval; disease free survival; early cancer diagnosis; mortality; mouth floor; mouth tumor; odds ratio; pathology; procedures; risk assessment; smoking; survival analysis; tumor invasion; young adult; Adult; Aged; Alcoholism; Cause of Death; Cheek; Cohort Studies; Confidence Intervals; Disease-Free Survival; Early Detection of Cancer; Female; Gingiva; Humans; Male; Middle Aged; Mouth Floor; Mouth Neoplasms; Neoplasm Invasiveness; Neoplasm Staging; Odds Ratio; Oropharynx; Palate, Hard; Prospective Studies; Risk Assessment; Smoking; Survival Analysis; Taiwan; Young Adultjournal article10.1002/hed.25579306523782-s2.0-85060137972