臺大醫院;臺大醫院-神經部;臺大醫院-精神醫學部;臺大醫學院;臺大醫學院-神經科;臺大醫學院-腦與心智科學研究所;臺大醫學院-精神科;Hsu, Yen-HsuanYen-HsuanHsuHuang, Ching-FengChing-FengHuangTu, Min-ChienMin-ChienTuHua, Mau-SunMau-SunHua2017-05-312018-07-092017-05-312018-07-092015http://ntur.lib.ntu.edu.tw//handle/246246/279290Accumulating evidence shows that subjective cognitive decline (SCD) without impairment on conventional neuropsychological tests may indicate increased risk for Alzheimer disease. Previous studies of mild cognitive impairment have demonstrated the potential role of prospective memory (PM) in the early detection of cognitive decline. We thus aimed to investigate the performance of people with SCD on PM tasks relative to their healthy controls (HCs). Forty-one participants with SCD and demographically matched HCs received regular cognitive testing as well as 2 single-trial naturalistic time-based and event-based PM tasks. Statistical analyses showed that the individuals with SCD performed worse on the time-based PM task, especially on the prospective component, when compared with their HCs. Our findings suggest that PM, especially the time-based one on the prospective component, may be an early cognitive marker of dementia. This implies an underlying difficulty among subjects with SCD in self-initiation that exacerbates their memory difficulties. Further investigation on a large scale is needed.prospective memorymild cognitive impairmentAlzheimer diseasesubjective cognitive impairmentsubjective memory impairmentcognitive complaintmemory complaintcognitive function[SDGs]SDG3adult; Alzheimer disease; attention; clinical article; cognition; cognitive defect; cognitive function test; controlled study; daily life activity; dementia; drawing; female; human; language; long term memory; male; middle aged; mild cognitive impairment; Mini Mental State Examination; orientation; priority journal; problem solving; prospective memory; retrospective memory; Review; self report; short term memory; subjective cognitive decline; task performance; time; aged; Alzheimer disease; dementia; early diagnosis; episodic memory; Memory Disorders; mild cognitive impairment; neuropsychological test; psychology; Adult; Aged; Alzheimer Disease; Dementia; Early Diagnosis; Female; Humans; Male; Memory Disorders; Memory, Episodic; Middle Aged; Mild Cognitive Impairment; Neuropsychological Tests10.1097/WAD.0000000000000060