CHIANG I-NISHANG-JEN CHANGYEONG-SHIAU PUKUO-HOW HUANGHONG-JENG YUCHAO-YUAN HUANG2020-01-232020-01-232009https://scholars.lib.ntu.edu.tw/handle/123456789/452991Introduction: We retrospectively compared 6- and 12-core prostate biopsies in Taiwanese men and evaluated the impact of prostate volume (PV), prostate-specific antigen (PSA), and PSA density (PSAD) on the prostate cancer detection rate (PCDR). Patients and Methods: 1,086 consecutive patients with a total PSA of 4.1-20.0 ng/ml and/or abnormal digital rectal examination undergoing first-time transrectal ultrasound-guided biopsy were included. Group I patients (n = 562) underwent sextant biopsy and group II patients (n = 524) underwent sextant biopsy with an extra three lateral cores on both sides. The patients were further stratified into subgroups according to PV (cut-off: 35 ml), PSA (cut-off: 10.0 ng/ml), and PSAD (cut-off: 0.2). Results: Prostate cancer was diagnosed in 228/1,086 (21.0%) patients. The PCDR was higher in group II (23.7%) than group I (18.5%). 12-Core biopsy yielded a significantly higher PCDR than 6-core biopsies in patients with PV >35 ml, PSA 4.1-10.0 ng/ml, PSAD ?0.20, but not in patients with PV ?35 ml, PSA 10.1-20.0 ng/ml, PSAD >0.20. Conclusions: 12-Core biopsy yielded a significantly higher PCDR in Taiwanese men with a total PSA of 4.1-20.0 ng/ml, especially in patients with PSA 4.1-10.0 ng/ml, PSAD ?0.20, and PV >35 ml. ? 2009 S. Karger AG, Basel.[SDGs]SDG3prostate specific antigen; adult; aged; antigen specificity; article; cancer diagnosis; controlled study; digital rectal examination; epididymitis; fever; hematuria; human; intermethod comparison; major clinical study; male; priority journal; prostate biopsy; prostate cancer; prostatitis; rectum hemorrhage; Taiwan; transrectal ultrasonography; tumor volume; urine retention; Aged; Biopsy, Needle; Digital Rectal Examination; Humans; Male; Middle Aged; Organ Size; Predictive Value of Tests; Prostate-Specific Antigen; Prostatic Neoplasms; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Taiwan; Ultrasonography, Interventionaljournal article10.1159/0002093562-s2.0-65949093051