Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development

Chiu, Kuan-ChihKuan-ChihChiuSisca, FranFranSiscaYing, Jen-HaoJen-HaoYingTsai, Wan-JuWan-JuTsaiWU-SHIUN HSIEHPAU-CHUNG CHENCHEN-YU LIU2023-03-062023-03-062021-04-010269-7491https://scholars.lib.ntu.edu.tw/handle/123456789/628949Chlorpyrifos, one of the most widely used pesticides, can penetrate the placenta and affect fetal growth and neurodevelopment. Epigenetic regulation of peroxisome proliferator-activated receptor gamma (PPARγ), such as DNA methylation and trimethylation of lysine 4 of H3 (H3K4me3), may provide a potential mechanism for how fetal growth and development are impacted by chlorpyrifos exposure. The aims of the study were to investigate whether prenatal chlorpyrifos exposure was associated with H3K4me3 and DNA methylation levels of the PPARγ gene in the placenta and the related effects on birth outcomes and neurodevelopment.enBirth cohort study; Epigenetics; PPARγ; Prenatal exposure; chlorpyrifos[SDGs]SDG1[SDGs]SDG3Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child developmentjournal article10.1016/j.envpol.2021.116511335402512-s2.0-85100269628WOS:000625379400029https://scholars.lib.ntu.edu.tw/handle/123456789/556676