臺大公衛學院-流行病學與預防醫學研究所;Lai, Shih WeiShih WeiLaiLiao, Kuan FuKuan FuLiaoLai, Hsueh ChouHsueh ChouLaiTsai, Pang YaoPang YaoTsaiSung, Fung ChangFung ChangSungChen, Pei ChunPei ChunChen2014-02-172018-06-292014-02-172018-06-292013http://ntur.lib.ntu.edu.tw//handle/246246/260044Introduction: The purpose of this study was to explore whether diabetes mellitus (DM) correlates with the risk of kidney cancer in Taiwan. Materials and Methods: We designed a population-based case-control study from the Taiwan National Health Insurance Database, which consisted of 116 patients with newly diagnosed kidney cancer as cases and 464 subjects without kidney cancer as controls in 2000 to 2009. Both cases and controls were aged >= 20 years. Baseline comorbidities were compared between kidney cancer cases and controls. Results: Multivariable analysis showed no association was detected between DM and kidney cancer (OR 1.06, 95% CI, 0.58 to 1.94). Hypertension (OR 2.05, 95% CI, 1.23 to 3.42), chronic kidney diseases (OR 2.57, 95% Cl, 1.23 to 5.37), cystic kidney diseases (OR 18.6, 95% CI, 1.84 to 187.6) and kidney stones (OR 4.02, 95% Cl, 2.43 to 6.66) were significant comorbidities associated with increased risk of kidney cancer. Use of alpha-glucosidase inhibitor was associated with increased risk of kidney cancer (OR 4.31, 95% CI, 1.07 to 17.3). Conclusion: DM does not correlate with the risk of kidney cancer. Hypertension, chronic kidney diseases, cystic kidney diseases, kidney stones and use of alpha-glucosidase inhibitors are associated with kidney cancer. Ann Acad Med Singapore 2013;42:120-4Chronic kidney diseaseCystic kidney diseaseDiabetes mellitusHypertensionKidney cancerKidney stone[SDGs]SDG3