Huang C.-L.YEN-WEN WUCHIH-CHENG WULIN, LINLINLINWu Y.-C.Hsu P.-Y.Jong Y.-S.WEI-SHIUNG YANG2021-03-182021-03-1820131475-2840https://scholars.lib.ntu.edu.tw/handle/123456789/553747Background: Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.Methods: A total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.Results: Compared with the patients with mild CAD (summed stress score [SSS] ? 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01-1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23-5.94; P = 0.013).Conclusions: Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD. ? 2013 Huang et al.; licensee BioMed Central Ltd.[SDGs]SDG3adiponectin; amino terminal pro brain natriuretic peptide; C reactive protein; creatinine; fatty acid binding protein; glucose; FABP4 protein, human; fatty acid binding protein; adult; aged; article; body mass; coronary artery disease; creatinine blood level; echocardiography; female; glucose blood level; heart failure; heart left ventricle ejection fraction; heart left ventricle function; heart muscle perfusion; human; major clinical study; male; protein blood level; risk factor; single photon emission computer tomography; stress echocardiography; waist circumference; blood; coronary artery disease; echography; heart left ventricle function; heart stroke volume; middle aged; multivariate analysis; myocardial perfusion imaging; scintiscanning; severity of illness index; statistical model; very elderly; Aged; Aged, 80 and over; Coronary Artery Disease; Echocardiography, Stress; Fatty Acid-Binding Proteins; Female; Heart Failure; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Myocardial Perfusion Imaging; Severity of Illness Index; Stroke Volume; Tomography, Emission-Computed, Single-Photon; Ventricular Dysfunction, Left; Ventricular Function, Leftjournal article10.1186/1475-2840-12-105238660222-s2.0-84880182897