外科HSU, RON-BINRON-BINHSU2008-12-162018-07-112008-12-162018-07-112005http://ntur.lib.ntu.edu.tw//handle/246246/91983BACKGROUND AND OBJECTIVE: Nosocomial infections caused by methicillin- resistant Staphylococcus aureus (MRSA) are increasing. Only a few studies of MRSA infective endocarditis have been conducted, and none have reported its risk factors. We sought to determine the host-related risk factors for infective endocarditis in patients with nosocomial MRSA bacteremia. SETTING: A 2,000-bed, university -affiliated, tertiary-care hospital. PATIENTS: Thirty-one patients with nosocomial MRSA infective endocarditis between October 1996 and May 2003. DESIGN: A retrospective chart review was conducted. Data were compared with those from a control group of patients with nosocomial MRSA bacteremia. Logistic regression was used to identify independent risk factors for nosocomial infective endocarditis. RESULTS: Compared with patients who had nosocomial MRSA bacteremia and no infective endocarditis, patients who had infective endocarditis had a higher incidence of chronic liver disease and a lower incidence of immunodeficiency. The risk of developing infective endocarditis was approximately 10% for patients with nosocomial MRSA bacteremia. CONCLUSION : Patients with MRSA bacteremia and underlying chronic liver disease were prone to infective endocarditis.en-USjournal article