MONG-WEI LINYEN-LIN HUANGYang C.-Y.SHUENN-WEN KUOCHEN-TU WUYIH-LEONG CHANG2020-03-072020-03-0720191068-9265https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056903927&doi=10.1245%2fs10434-018-6993-5&partnerID=40&md5=2daa757898a89cb3564b58f15d6b234fhttps://scholars.lib.ntu.edu.tw/handle/123456789/473730Background: Pulmonary peripheral-type squamous cell carcinoma (p-SqCC) has been increasing in incidence. However, little is known about the clinicopathologic features of p-SqCC. This study aimed to investigate the clinicopathologic characteristics and clinical outcomes of p-SqCC compared with central-type SqCC (c-SqCC) in a large cohort of surgically resected lung SqCC patients with long-term follow-up results. Methods: The study included 268 patients with SqCC who underwent surgical resection at the authors’ institute from January 1990 to September 2013. The mean follow-up period was 67.1?months. The clinicopathologic and genetic characteristics were investigated in relation to their association with progression-free survival (PFS) and overall survival (OS) based on tumor location. Results: The study cohort included 120 patients with p-SqCC and 148 patients with c-SqCC. Compared with c-SqCC, p-SqCC was correlated with older age (p = 0.002), female sex (p = 0.033), better performance status (p < 0.001), smaller tumor (p = 0.004), less lymph node metastasis (p < 0.001), and an earlier pathologic stage (p < 0.001). Despite the clinicopathologic differences, tumor location was not significantly correlated with clinical outcomes. For the p-SqCC patients, the multivariate analysis showed a significant correlation of lymphovascular invasion (PFS, p < 0.001; OS, p < 0.001) and lymph node metastasis (p = 0.007; OS, p = 0.022) with poor PFS and OS, but a significant correlation of incomplete tumor resection (PFS, p = 0.009) only with poor PFS. Conclusions: The clinicopathologic features differed between the p-SqCC and c-SqCC patients. Lymphovascular invasion and lymph node metastasis were independent prognostic factors of p-SqCC. These prognostic factors may be potentially used as indicators for adjuvant therapies to be used with patients who have p-SqCC. ? 2018, Society of Surgical Oncology.[SDGs]SDG1[SDGs]SDG3adult; aged; Article; cancer patient; cancer prognosis; cancer staging; cancer surgery; cancer survival; central-type squamous cell carcinoma; clinical outcome; computer assisted tomography; disease association; female; follow up; human; long term care; lung lobectomy; lung resection; lymph node dissection; lymph node metastasis; lymph vessel metastasis; major clinical study; male; multivariate analysis; nuclear magnetic resonance imaging; overall survival; physical examination; positron emission tomography; progression free survival; pulmonary peripheral type squamous carcinoma; squamous cell lung carcinoma; surgical margin; surgical oncology; surgical risk; thorax radiography; tumor recurrence; video assisted thoracoscopic surgery; cohort analysis; lung surgery; lung tumor; middle aged; mortality; non small cell lung cancer; pathology; prognosis; squamous cell carcinoma; survival rate; tumor invasion; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cohort Studies; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Pulmonary Surgical Procedures; Survival Ratejournal article10.1245/s10434-018-6993-5304566762-s2.0-85056903927