2011-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/647576摘要：目前一般診所常見的冷光美白、雷射美白等所使用的美白藥劑，以過氧化氫的漂白藥劑為主，利用光源(熱催化)來加速過氧化氫分解成氫氧自由基去分解牙齒中的色素，但是目前漂白藥劑及光照漂白方法其漂白效果有限，有時會產生一些副作用像是牙齒敏感或牙根吸收。本計畫主要目的是合成能抓住過渡金屬離子的中孔洞奈米粒子以催化過氧化氫溶液，藉由快速產生氫氧自由基去分解色素，縮短漂白的時間，減少漂白藥劑對牙齒的傷害。我們將合成各種不同的M+-his-MSN 漂白催化劑，包括Fe2+, Mn2+, Cu2+，以及中孔洞(氧化鈦、氧化鋯、氧化鋁)漂白催化劑，本計畫預計執行三年，第一年的主要目標為合成各種不同的漂白催化劑，並以UV-Vis spectrometer 及拔除牙齒的染色模型評估過氧化氫加入各種不同的催化劑對於Orange II 及牙齒染色的漂白效果。第二年的主要目標為以SEM-EDS, TEM-EDS, ICP-MS, XRD, NMR, N2 adsorption/desorptionisotherms, BET and BJH methods 對漂白催化劑材料的各種性質做分析。第三年的主要目標為評估漂白催化劑之生物相容性，包括評估漂白催化劑對細胞生物功能及骨生成相關基因表現的影響。經由以上三年之整體實驗規劃，將研發一種有效提昇過氧化氫漂白效果之催化劑，且生物相容性高的材料，最後則會申請專利、產品化、進行臨床試驗以及發表在學術期刊。<br> Abstract: Hydrogen peroxide with LED or laser irradiation is the major method used for officebleaching. The light sources are used to accelerate the breakdown of H2O2 for generation offree radical (·OH) and then the free radical will attack the pigment in the tooth. However, thecurrent bleaching efficacy is limited and some side effects such as tooth hypersensitivity androot absorption may occur. The aim of this project is to synthesize different mesoporous silicananoparticles (MSN) immobilized with metal ion-histidine complex including Fe2+, Mn2+, andCu2+. Other types of mesoporous nanoparticles including titanium oxide, zirconium oxide,and aluminum oxide will also be fabricated. This project is designed in three years with theaim of the first year is to synthesize metal ion-histidine complex immobilized mesoporousnanoparticles for enhancement of tooth bleaching efficiency. UV-Vis spectrometer andextracted stained tooth model are used to evaluate the bleaching efficiency of differentcatalysts. The aim of the second year is to characterize the properties of catalysts usingSEM-EDS, TEM-EDS, ICP-MS, XRD, NMR, N2 adsorption/desorption isotherms, BET andBJH methods. Finally, the aim of the third year is to evaluate the biocompatibility and boneformation-related gene expression of the material. After three years of research, a newmaterial with good in vitro performance and high biocompatibility will be developed.Ultimately, we will apply the patent, commercialize the product, perform the clinical trial, andpublish the paper in scientific journal.牙齒美白過氧化氫中孔洞奈米粒子tooth bleachinghydrogen peroxidemesoporous nanoparticles