Lin, Y.-C.Y.-C.LinKe, Z.-Y.Z.-Y.KeLiao, P.-H.P.-H.LiaoTseng, C.-Y.C.-Y.TsengKIEN-VOON KONG2021-01-272021-01-272020https://www.scopus.com/inward/record.url?eid=2-s2.0-85078373531&partnerID=40&md5=792cd1e1a494926cfa1ad7be41c7363ahttps://scholars.lib.ntu.edu.tw/handle/123456789/543309The detection of cancer invasion is crucial for diagnosis. In this report, we employed a TERS tip and SERS nanotags to create a cell signaling based nano-sensing system. This system is capable of creating a reversible phosphorylation/de-phosphorylation cycle for TERS measurement. The reversible TERS sensing is then paired with a downstream binding domain, Src homology region 2 (SH2), which is associated with the cell signaling for cancer cell invasion. Such a system offers the advantages of convenient detection of nanotags and high sensitivity as validated in a cell model. ? 2020 The Royal Society of Chemistry.[SDGs]SDG3cyclopentadienyl ruthenium; nanoparticle; nanotag; phosphatase; protein SH2; ruthenium derivative; unclassified drug; Article; cancer cell; cell invasion; chemical structure; controlled study; human; human cell; MCF-7 cell line; MDA-MB-231 cell line; nonhuman; phosphorylation and dephosphorylation; protein binding; protein domain; sensitivity analysis; signal transduction; surface enhanced Raman spectroscopy; transmission electron microscopy; Yersinia pseudotuberculosisjournal article10.1039/c9cc08269g318504092-s2.0-85078373531WOS:000510498100015