Chang, YYYYChangYang, DJDJYangChiu, CHCHChiuYU-LIN LINChen, JWJWChenYI-CHEN CHENCHIH-HSIEN CHIU2019-09-262019-09-2620131756-4646https://scholars.lib.ntu.edu.tw/handle/123456789/425200Gentisic acid and epicatechin are two major compounds in phenolic acids and flavonoids of litchi-flower-water extracts (LFWEs), respectively. Increased (p< 0.05) serum lipids and liver size/lipid, damage/inflammatory indices, TBARS value, CRP level, MMP-9 activity, and decreased (p< 0.05) liver GSH and TEAC levels, and SOD, CAT and GSH-Px activities were observed in high-fat-diet fed hamsters compared to normal-fat-dietary hamsters. Those biochemical values of high-fat-diet fed hamsters were significant improved (p< 0.05) by drinking LFWEs. In addition, these improvements on liver damage induced by a high-fat diet were also evidenced in the histopathological examination of livers where less microvesicular steatosis and no necrotic/inflammatory cells were observed in high-fat-diet fed hamster drinking LFWEs. Therefore, protective effects of LFWEs on liver damage of high-fat-diet fed hamsters can be accounted for antioxidative properties and anti-inflammatory effects of LFWEs. © 2012 Elsevier Ltd.Antioxidative capacity; Hepatic lipids; Litchi-flower-water-extract; Liver cytokine level; Liver damage index; Matrix metalloproteinase; Nonalcoholic fatty liver; Polyphenolic profile10.1016/j.jff.2012.08.0022-s2.0-84873266812WOS:000315241500007https://api.elsevier.com/content/abstract/scopus_id/84873266812