Yi-Siou ChiouPei-Sheng LeeMIN-HSIUNG PAN2018-09-102018-09-102018-01https://doi.org/10.1021/acs.jafc.7b05854http://scholars.lib.ntu.edu.tw/handle/123456789/402403Current views support the concept that obesity is linked to a worsening of the course of inflammatory bowel diseases (IBDs). Gut microbiota and adipose tissue macrophage (ATM) are considered key mediators or contributors in obesity-associated intestinal inflammation. Dietary components can have direct or indirect effects on "normal" or "healthy" microbial composition and participate in adiposity and metabolic status with gut inflammation. In this perspective, we highlight food-derived bioactives that have a potential application in the prevention of obesity-exacerbated IBD, targeting energy metabolism, M1 (classical activated)-M2 (alternatively activated) macrophage polarization, and gut microbiota. ? 2018 American Chemical Society.ATM; bioactives; gut microbiota; IBD; obesity[SDGs]SDG2[SDGs]SDG3Automatic teller machines; Macrophages; Metabolism; Pathology; Bioactives; Dietary components; Energy metabolism; Gut microbiota; Inflammatory bowel disease; Intestinal inflammation; Microbial composition; obesity; Nutrition; phytochemical; adipose tissue; complication; diet; drug effects; energy metabolism; human; inflammatory bowel disease; intestine flora; macrophage; macrophage activation; microbiology; obesity; pathophysiology; physiology; Adipose Tissue; Adiposity; Diet; Energy Metabolism; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases; Macrophage Activation; Macrophages; Obesity; Phytochemicalsjournal article10.1021/acs.jafc.7b05854