2024-05-182024-05-1864759https://scholars.lib.ntu.edu.tw/handle/123456789/718943Pain medicineCancer pain management疼痛醫學Mechanism of neuropathic pain and opioid toleranceOpioid induced hyperalgesiaUltrasound guided regional anesthesia pain management and vascular accessImage guided neuroablative and neuromodulatory proceduresPain Psychology進階癌症疼痛控制影像導引區域麻醉與疼痛處置人工血管處置疼痛心理學My major research interests are mechanisms and possible therapeutic approaches of neuropathic pain and morphine tolerance. Currently I am a PhD candidate of Institute of Pharmacology, National Taiwan University. In our lab, we use rat L5 spinal nerve ligation transection technique as neuropathic pain model. We use rat intrathecal catheterization to deliver morphine and induce tolerance. Recently we shift study focus to the contribution of glial activation (microglia and astroglia) on neuropathic pain and morphine tolerance. We also use primary glial culture to explore the possible signaling pathway underlying morphine or injury induced glial activation.