流行病學研究所;Graduate Institute of EpidemiologyLin, S-CS-CLinChou, Y-CY-CChouWu, M-HM-HWuWu, C-CC-CWuLin, W-YW-YLinYu, C-PC-PYuYu, J-CJ-CYuYou, S-LS-LYouChen, C-JC-JChenSun, C-AC-ASun2008-10-032018-06-292008-10-032018-06-292005http://ntur.lib.ntu.edu.tw//handle/246246/82065This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O- methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.(C) 2005 Lippincott Williams & Wilkins, Inc.en-USbreast cancercatechol-O-methyltransferasepolymorphismsmyeloperoxidaseoestrogen exposure[SDGs]SDG3journal article