MAO-YUAN SUVIN-CENT WUHSI-YU YUYEN-HUNG LINKuo C.-C.KAO-LANG LIUSHUO-MENG WANGSHIH-CHIEH CHUEHLIAN-YU LINKWAN-DUN WUWEN-YIH TSENG2020-03-032020-03-0320121053-1807https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862063466&doi=10.1002%2fjmri.23592&partnerID=40&md5=e9e571b442098e86f25089f1441285c1https://scholars.lib.ntu.edu.tw/handle/123456789/468750Purpose: To assess the degree of myocardial fibrosis in patients with primary aldosteronism (PA). Materials and Methods: Twenty-five patients with PA and 12 age-matched healthy volunteers underwent cine and late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) on a 1.5 T MR system. From volume-time curves of cine MRI, the time for deceleration (Tdec) was determined to assess the left ventricle (LV) chamber stiffness. Based on phase-sensitive reconstructed LGE images, a fibrosis index called enhancement value (EV) was computed as the signal intensity change in the myocardium over blood before and after contrast. Both Tdec and EV were compared between patients and controls. The association between Tdec and EV was investigated. Results: Patients showed a significantly higher EV (0.43 ± 0.05 vs. 0.36 ± 0.07; P = 0.002) and a significantly shorter Tdec (11.5 ± 3.5 %RR vs. 15.3 ± 2.4 %RR; P = 0.004) than controls. Significant correlations between EV and Tdec were observed in patients (r = -0.46, P = 0.018), in controls (r = -0.68, P = 0.015) and in all subjects (r = -0.63, P < 0.001). Conclusion: The fibrosis index is increased in patients with PA and the increase imposes an adverse effect on LV diastolic function. Copyright ? 2012 Wiley Periodicals, Inc.[SDGs]SDG3gadolinium; adult; article; blood pressure measurement; clinical article; contrast enhanced magnetic resonance imaging; controlled study; coronary artery disease; diabetes mellitus; diagnostic value; diffuse myocardial fibrosis; female; heart left ventricle; heart left ventricle filling; heart muscle fibrosis; human; image analysis; image display; image enhancement; infection; male; nuclear magnetic resonance imaging; primary hyperaldosteronism; priority journal; valvular heart disease; Algorithms; Contrast Media; Endomyocardial Fibrosis; Female; Gadolinium DTPA; Humans; Hyperaldosteronism; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificityjournal article10.1002/jmri.23592222824062-s2.0-84862063466