2016-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/657850摘要：至2014年底護理人員共有146,453位，逾醫療人員總數之1/2，其中98.18%為女性， 而女性護理人員中73.7%為20〜40歲之育齡期婦女。護理人員工作特性之一為需要輪班， 而輪班所帶來的睡眠問題及身、心理疲勞、工作場所可能有抗癌藥物的暴露、化學物質，及 醫療工作本身所帶來的極大身心壓力等，因此常見許多國内外研究個別探討各變項對於女性 護理人員月經異常、受孕所需時間、及對懷孕結果（是否早產、流產、出生體重不足）影響 的相關性，但尚缺乏更全面性研究，包括進入職場後體内賀爾蒙濃度變化之長期追蹤研究資 料。本研究包括三年追蹤性研究，主要探討自變項（包括一般工作情形、輪班、睡眠狀況及 品質、身心狀況、護理工作壓力源、特殊工作暴露、搬重物、工作時數、輪班情形等）及簡 式健康量表BSRS-5，與依變項（包括月經週期變化、月經出血持續天數與量、經期規則性、 體内賀爾蒙濃度變化等）之相關性。預期將達成下列目標：（1) 了解女性護理人員在職場中所面臨的各項職業暴露對於其生 殖健康所造成的影響。（2)提供我國護理從業人員職業暴露與生殖健康效應的長期追蹤資訊。 (3)建立女性護理人員工作健康的世代研究。<br> Abstract: As of 2014, there were 146,453 registered nurses in Taiwan, which accounted for more than a half of all health workers. While 98.18% nurses were female, and about 73.7% of these female nurses were of childbearing age, whose age were between 20~40 year-old. As part of the job characteristics, nurses have to take the shift work. Facing the change of sleeping patterns, physical- mental fatigue, potential exposure to antineoplastic drugs and other chemicals, and even stress from work has been a heavy yoke to clinical nurses. Therefore, numbers of research topics have been discussing the association between shifting duty and several outcomes related to gynecology and obstetrics, such as menstrual abnormalities, challenge of fertilization and health conditions of neonates-including preterm, abortion and low birth weight. However, limited correlation researches were done in Taiwan, and no comparisons about overall gynecology and obstetrics abnormalities among nurses who were under shifting duties. Most important, there are no longitudinal data and records about endocrine changes among female clinical nurses.In this 3-year cohort study design, we will collect menstruation cycles of graduating students in four nursing schools, and we will compare these data with those after they enter the nursing care work. We’d like to evaluate all the variables including rotating shift work, sleeping problems resulting from shift work, special occupational exposures (antineoplastic drugs, anesthetic gases, antiviral drugs, sterilizing agents, X-rays, and heavy-lifting), occupational stress, burnout resulting from occupational stress, and changes of their hormones. In the following year, we’ll chose 30 female nurses who rotate in different shift from our study population, and we’ll collect their urine sample to examine the change of urinary 6-sulfatoxymelatonin and hormone levels in aims to determine the effect of medical care work to reproductive function of female nurses.There are three goals this study intends to achieve:(1)To determine the occupational exposures that female nurses confront, and their effect to reproductive function of female nurses.(2)To provide the long-term following up data for occupational exposures and the effect of reproductive health of female nurses in our country, so it will also become the evidence base to improve occupational environment and reduce the risk of female nurses.(3)To establish a cohort study of occupational health in female nurses, and establish the first data bank collecting occupational exposures and the health effect of nursing profession in the nation.