職醫與工衛所CHENG, TSUN-JENTSUN-JENCHENG2008-10-092018-06-292008-10-092018-06-292000http://ntur.lib.ntu.edu.tw//handle/246246/83465The genotoxicity of low-level exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) in humans is not clear. We used lymphocyte sister chromatid exchange ( SCE) frequency as a parameter to investigate the genotoxicity of low level EDC and VCM in VCM-manufacturing workers. The SCE frequency was determined for 51 male workers with exposure to VCM and/or EDC and for 20 male workers devoid of such exposure. Epidemiological data were obtained by questionnaire, and included history of smoking, drinking, and any medication taken, as well as a detailed occupational history. Personal- and area-sampling and analysis were conducted in order to calculate the time- weighted average (TWA) contaminant-exposure level corresponding to different job categories. Moderate EDC exposure around 1 ppm corresponded to a significantly greater SCE frequency than was the case for the low EDC exposure group (p<0.01). However, VCM exposure of similar level was not associated with increased SCE. We conclude that EDC may cause genotoxicity at a relatively low level of exposure. (C) 2000 Elsevier Science B.V. All rights reserved.en-USsister chromatid exchangesmokingvinyl chlorideethylene dichloridejournal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/83465/1/14.pdf