Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Su, J.-C.J.-C.SuHuang, Y.-T.Y.-T.HuangChen, C.-S.C.-S.ChenHAO-CHIEH CHIUShiau, C.-W.C.-W.Shiau2021-05-282021-05-282018-011420-3049https://scholars.lib.ntu.edu.tw/handle/123456789/563421Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.enStaphylococcus aureus; antibiotics; malonamide[SDGs]SDG3Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureusjournal article10.3390/molecules23010027292719462-s2.0-85039730510http://www.scopus.com/inward/record.url?eid=2-s2.0-85039730510&partnerID=MN8TOARS41406796