Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations

Solomon, B JB JSolomonLoong, H HH HLoongSummers, YYSummersThomas, Z MZ MThomasFrench, PPFrenchLin, B KB KLinSashegyi, AASashegyiWolf, JJWolfCHIH-HSIN YANGDrilon, AADrilon2023-03-022023-03-022022-0420597029https://scholars.lib.ntu.edu.tw/handle/123456789/628830The number of randomized trials of agents targeting oncogene-addicted tumors has surged in the past 10 years. Using a meta-analysis, we explored whether improvements in objective response rate (ORR) in comparative trials using targeted agents could serve as a potential surrogate endpoint for improvements in progression-free survival (PFS) or overall survival (OS) in populations with oncogene-addicted cancer.encorrelation; meta-analysis; objective response rate; overall survival; progression-free survival; targeted therapy[SDGs]SDG3Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populationsjournal article10.1016/j.esmoop.2022.100398351830432-s2.0-85124627109WOS:000819921700028https://api.elsevier.com/content/abstract/scopus_id/85124627109