許寬立2006-07-262018-07-112006-07-262018-07-112002http://ntur.lib.ntu.edu.tw//handle/246246/23544本研究目的在於探討血管張力素 元、張力素轉化與第一型張力素受器 基因之haplotype 是否與本態性高血壓 有關。方法：共有408 位病人與286 位 正常人鑑定上述三種基因之多態型。利 用permutation 為基礎的假設分析三種 基因haplotypes 與高血壓之關連，並分 析個別基因之互相作用。結果發現血管 張力素元基因之haplotype 與高血壓有 關。而此種關連只見餘於張力素轉化 基因為II 型者。因此高血壓之關連研 究，有基因之間的互相作用存在。There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homogeneous Taiwanese population. We also genotyped angiotensin converting enzyme gene insertion/ deletion polymorphism and angiotensin II type I receptor gene A1166C polymorphism to detect epistatic gene-gene interactions. There were 408 patients with hypertension (hypertensives) and 286 controls. The angiotensinogen gene haplotype frequencies were significantly different between hypertensives and controls, and this finding was only present in subjects with angiotensin converting enzyme gene II genotypes when the analysis was stratified by genotype of this polymorphism. In addition, the angiotensinogen gene hyplotype structure of hypertensives was more heterogeneous than that of controls. Our results showed that angiotensinogen gene haplotypes were associated with hypertension, and might play a synergistic action with I allele of angiotensin converting enzyme gene.application/pdf88516 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科血管張力素元張力素轉化高血壓基因型互相作用AngiotensinogenAngiotensin-converting enzymeHypertensionHaplotypeInteractionreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23544/1/902314B002214.pdf