Chang J.-Y.Yu W.-H.Juan H.-F.Huang H.-C.2020-01-222020-01-2220180006291Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/452352Alternative polyadenylation (APA) affects the length of the 3′ untranslated region (3′-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3′-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3′-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3′-UTRs tended to become longer, and gene expression was negatively correlated with 3′-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3′-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development. ? 2018 Elsevier Inc.[SDGs]SDG3long untranslated RNA; long untranslated RNA; RNA isoform; 3' untranslated region; Article; cancer cell; correlational study; developmental stage; embryo; embryo development; gene expression; genetic variation; genome imprinting; human; polyadenylation; preimplantation embryo; priority journal; trend study; blastocyst; gene expression regulation; gene regulatory network; genetic database; genetics; metabolism; nucleotide sequence; 3' Untranslated Regions; Base Sequence; Blastocyst; Databases, Genetic; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Humans; Polyadenylation; RNA Isoforms; RNA, Long Noncodingjournal article10.1016/j.bbrc.2018.09.0272-s2.0-85053021119https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85053021119&doi=10.1016%2fj.bbrc.2018.09.027&partnerID=40&md5=25358e3749c7dc395f4ebdfe4d41dcbe