檢驗醫學科LEE, YUAN-TIYUAN-TILEETSAUR, SHYH-MINGSHYH-MINGTSAURLEE, MENG-CHIHMENG-CHIHLEEHSUEH, PO-RENPO-RENHSUEH2011-06-212018-07-122011-06-212018-07-122010http://ntur.lib.ntu.edu.tw//handle/246246/235656The present study investigated the long-term impact of antibiotic use policy on the rates of consumption (expressed as daily-defined doses/1000 patient-days) of various parenteral antibiotics and on the prevalence of methicillin- resistant Staphylococcus aureus (MRSA) and the incidence of healthcare-associated MRSA (HA-MRSA) infection at a tertiary care hospital from 2001 to 2009. During this time, consumption of all antimicrobials for systemic use decreased by 33%. This change was driven by a 44% decrease in the consumption of unrestricted antibacterials, which was offset by a 42% increase in the consumption of restricted agents. The trends in MRSA prevalence (number of isolates/1000 patient-days) and HA- MRSA incidence (number of HA-MRSA- infected persons/1000 patient-days) correlated with the trend in overall consumption of antimicrobials. Significant positive correlations were observed between MRSA prevalence and the consumption of extended-spectrum and beta-lactamase- resistant penicillins, first-generation cephalosporins, macrolides, lincosamides and streptogramins, aminoglycosides , and glycopeptides. Significant positive correlations were found between the incidence of HA-MRSA infection and the consumption of tetracyclines, extended-spectrum and beta- lactamase- resistant penicillins, sulfonamides and trimethoprim, macrolides, lincosamides and streptogramins, and aminoglycosides. In conclusion, we have documented the ongoing successful reduction in total consumption of antimicrobials associated with a decrease in the incidence of HA-MRSA and the prevalence of MRSA over a 9-year period.en-USAntibiotic consumptionHealthcare-associated infectionMethicillin-resistantStaphylococcus aureusCorrelationTaiwan