方俊民臺灣大學：化學研究所曾俊豪Tseng, Chun-HaoChun-HaoTseng2007-11-262018-07-102007-11-262018-07-102007http://ntur.lib.ntu.edu.tw//handle/246246/52002In this thesis, we plan to use a simple linker which can directly conjugate with sugar and peptide without any modification on the peptide and saccharide. Compound 1 is the crosslinker designed for conjugation with unmodified sialic acid and peptide. Compound 1 reacted with sialic acid to give quinoxalinone derivatives 22. Compound 26 underwent photoligation with n-butylamine to give 3H-azepine derivatives 27, and the gradual disappearance of the azido phenyl group was shown by the UV-Vis spectrum.目錄 ……………………………………………………………I 圖目錄 ……………………………………………………………11 流程目錄 ……………………………………………………………V 表目錄 ……………………………………………………………Vl 化學符號縮寫………………………………………………………Vll 中文摘要 ……………………………………………………………IX 英文摘要 ……………………………………………………………X 壹、緒論 ……………………………………………………………1 緒論…………………………………………………………………… 1 一、醣化工具的應用……………………………………………………1 二、唾液酸的重要性………………………………………………… 10 三、唾液酸的分析方法……………………………………………… 12 貳、結果與討論……………………………………………………… 15 一、鄰苯二胺連接試劑的設計與合成……………………………… 15 二、鄰苯二胺連接試劑與唾液酸的環化縮合反應………………… 23 三、鄰苯二胺連接試劑與親核劑的擴環加成反應………………… 33 四、鄰苯二胺類化合物與酮酸醣及離氨基酸之衍生化的改善策略 42 參、結論……………………………………………………………… 47 肆、實驗部分………………………………………………………… 48 一、一般敘述………………………………………………………… 48 二、實驗步驟與光譜數據…………………………………………… 50 伍、參考文獻………………………………………………………… 67 陸、附錄……………………………………………………………… 753625523 bytesapplication/pdfen-US唾液酸連接試劑喹喔啉酮疊氮苯胜肽sialic acidcrosslinkerquinoxalinonephotoligationpeptidethesishttp://ntur.lib.ntu.edu.tw/bitstream/246246/52002/1/ntu-96-R94223009-1.pdf