TIEN-CHUN CHANGChen W.-L.Chang W.P.Chen C.-J.2020-06-032020-06-0320010955-3002https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034766529&doi=10.1080%2f09553000110073420&partnerID=40&md5=032cdf4f48dd1f4eead7dbfff2c4d31ahttps://scholars.lib.ntu.edu.tw/handle/123456789/496693Purpose: To evaluate prolonged low dose-rate γ-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. Materials and methods: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (? 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of ?15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of ?15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of ? 15 years.[SDGs]SDG3cobalt 60; liothyronine; adolescent; adult; article; aspiration cytology; building; child; dose response; echography; female; goiter; human; liothyronine blood level; major clinical study; male; physical examination; priority journal; radiation dose; radiation exposure; thyroid function; thyroid gland; thyroid nodule; Adolescent; Building Codes; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Environmental Exposure; Female; Humans; Male; Prevalence; Radiation Effects; Regression Analysis; Taiwan; Thyroid Diseases; Thyroid Function Tests; Thyroid Glandjournal article10.1080/09553000110073420116839822-s2.0-0034766529