KUO-LIONG CHIENTA-CHEN SUHsu, Hsiu-ChingHsiu-ChingHsuWEI-TIEN CHANGChen, Pei-ChungPei-ChungChenChen, Ming-FongMing-FongChenLee, Yuan-TehYuan-TehLee2020-03-122020-03-122010-03-040167-5273https://scholars.lib.ntu.edu.tw/handle/123456789/475866https://www.scopus.com/record/display.uri?eid=2-s2.0-77249132695&doi=10.1016%2fj.ijcard.2008.10.045&origin=inward&txGid=c997804264171624dbd5082bb380c608Background: We investigated atrial fibrillation (AF) prevalence, incidence and the risk of stroke and all-cause death because little is known about AF risk among ethnic Chinese. Methods: We conducted a community-based prospective cohort study among 3560 participants. Prevalent and incident AF was documented by using the 12-lead ECG in baseline and serial follow-ups, and the stroke and all-cause death events were ascertained. Results: Overall prevalence rates of AF in the cohort were 1.4% in men and 0.7% in women. Incidence rates of AF were 1.68 per 1000 person-years for men and 0.76 per 1000 person-years for women. During a median 13.8?years' follow-up, we documented 208 cases of stroke and 776 deaths. As compared with those without AF, participants with AF had nearly 4 times the age, gender-adjusted risk of stroke (relative risk [RR], 3.87, 95% confidence interval [CI], 2.12-7.15), and twice the risk of death associated with all causes (RR, 2.23, 95% CI, 1.52-3.27). Further adjustment for body mass index, lifestyle factors, socioeconomic status and clinical diseases slightly attenuated these risks. In addition, after adjusting for echocardiographic measures, the following risks remained significant: the multivariate RRs were 2.90 (95% CI, 1.28-6.59) for risk of stroke and 2.05 (95% CI, 1.27-3.32) for risk of all-cause death among participants with AF. Conclusion: Our data demonstrate that AF is a significant risk factor for stroke and all-cause death for the Chinese. ? 2008 Elsevier Ireland Ltd. All rights reserved.enAtrial fibrillation; Chinese; Community-based cohort[SDGs]SDG3adult; age distribution; aged; article; body mass; cardiovascular risk; cause of death; Chinese; cohort analysis; electrocardiogram; female; follow up; gender; heart atrium fibrillation; human; incidence; lifestyle; major clinical study; male; prevalence; priority journal; prospective study; risk factor; socioeconomics; stroke; Adult; Aged; Asian Continental Ancestry Group; Atrial Fibrillation; Female; Humans; Incidence; Kaplan-Meiers Estimate; Life Style; Male; Middle Aged; Prevalence; Prospective Studies; Risk Factors; Socioeconomic Factors; Stroke; Taiwanjournal article10.1016/j.ijcard.2008.10.045190466082-s2.0-77249132695