Wu K.-C.CHUN-JUNG LIN2021-06-042021-06-04201910219498https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057987780&doi=10.1016%2fj.jfda.2018.11.005&partnerID=40&md5=733dd64fc2fbfa6acfb53175ae378610https://scholars.lib.ntu.edu.tw/handle/123456789/565062Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences regarding the aberrant expression of these drug-processing proteins in several inflammatory diseases and age-related disorders are provided. ? 2018Drug-metabolizing enzyme; Inflammation; Membrane transporter; Pharmacokinetics[SDGs]SDG3cell nucleus receptor; cytokine; drug metabolizing enzyme; immunoglobulin enhancer binding protein; carrier protein; drug; aging; degenerative disease; enzyme regulation; gene control; human; inflammation; inflammatory bowel disease; inflammatory disease; insulin dependent diabetes mellitus; metabolic disorder; nonhuman; protein expression; protein function; Review; rheumatoid arthritis; age; animal; enzymology; genetics; inflammation; metabolism; pharmacokinetics; Age Factors; Animals; Inflammation; Membrane Transport Proteins; Pharmaceutical Preparations; Pharmacokineticsreview10.1016/j.jfda.2018.11.005306485942-s2.0-85057987780