C.-C. ShenY.-H. ChouPAI-CHI LI2018-09-102018-09-102005-0309296441http://scholars.lib.ntu.edu.tw/handle/123456789/318075https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745594564&doi=10.1016%2fS0929-6441%2809%2960073-4&partnerID=40&md5=592b3241e906f6f4f5a59ddf48c0f5d9Pulse inversion (PI) technique plays an important role in ultrasonic nonlinear imaging. For tissue imaging, PI technique provides suppression of spectral leakage and, thus, produces better image contrast. For contrast imaging, contrast between the agents and surrounding tissues are also enhanced with this technique by distinguishing nonlinear microbubbles from the background in either Doppler domain or radiofrequency domain. This paper reviews the theoretical backgrounds and relevant issues of the PI technique. Improvements in image contrast with the PI technique in both tissue harmonic imaging and contrast harmonic imaging are discussed in detail. In addition, potential motion artifacts and related contrast degradation are also included. © Elsevier & CTSUM. All rights reserved.Contrast detection; Motion artifacts; Nonlinear imaging; Pulse inversion; Ultrasonic contrast agentscontrast medium; nc 100100; shu 508; artifact; B scan; contrast enhancement; contrast medium extravasation; contrast radiography; diagnostic accuracy; diagnostic value; digital filtering; Doppler echography; Doppler flowmetry; echography; hepatography; human; image display; image quality; intermethod comparison; liver injury; microbubble; normal distribution; radiocardiography; radiofrequency; review; signal noise ratio; soft tissue radiography; vascular tumor; waveformjournal article10.1016/s0929-6441(09)60073-42-s2.0-33745594564