CHUN-MING HONGCHUN-JEN LIUShiou-Hwei YehPEI-JER CHEN2021-06-252021-06-2520170929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009179157&doi=10.1016%2fj.jfma.2016.11.014&partnerID=40&md5=4a9e8a2bea3c2e661391fe0844af5247https://scholars.lib.ntu.edu.tw/handle/123456789/566836Background/purpose Daclatasvir is a nonstructural protein 5A inhibitor with potent activity against hepatitis C virus genotypes 1–6 in?vitro, and asunaprevir is a nonstructural protein 3 protease inhibitor with activity against genotypes 1, 4, 5, and 6. Despite a 90% sustained virologic response (SVR) rate, the SVR rate in patients with baseline NS5A-L31/Y93H polymorphisms decreased to around 40%. Therefore, an alternative regimen under the consideration of cost-effectiveness would be important. Whether the addition of ribavirin could improve the SVR rate among this group of patients remains unknown and hence our case series was reported. Methods For six adult chronic hepatitis C 1b patients with a pre-existing NS5A-Y93H (>20%) polymorphism, we added ribavirin (800?mg/d) to daclatasvir/asunaprevir for 24 weeks and followed through 12-weeks post-treatment. Four of these patients received interferon/ribavirin treatment before but relapsed, while the other two were na?ve cases. Two of them had liver cirrhosis and one had hepatocellular carcinoma postcurative therapy. The primary efficacy end-point was undetectable hepatitis C virus RNA (hepatitis C virus RNA level of?<?25?IU/mL) at 12 weeks after the end of the treatment (SVR12). Results In total, five cases reached SVR12 eventually (SVR rate: 83%; 95% confidence interval: 18.6–99.1%). However, the viral load of one remaining patient rebounded from the 24th week of treatment. No patients developed significant adverse effects during and after the treatment. Conclusion In genotype 1b chronic hepatitis C patients with NS5A-Y93H polymorphism, the addition of ribavirin to daclatasvir/asunaprevir may increase the SVR12 rate with minimal side effects, and thus deserves more comprehensive trials in resource-limited areas. ? 2016[SDGs]SDG3alanine aminotransferase; asunaprevir; creatinine; daclatasvir; nonstructural protein 5A; peginterferon; ribavirin; virus RNA; antivirus agent; asunaprevir; BMS-790052; imidazole derivative; isoquinoline derivative; NS-5 protein, hepatitis C virus; ribavirin; sulfonamide; viral protein; adult; adverse outcome; aged; Article; Child Pugh score; chronic hepatitis C; clinical article; decompensated liver cirrhosis; drug efficacy; drug safety; female; fever; flushing; follow up; hematocrit; Hepatitis C virus subtype 1b; human; liver cell carcinoma; male; middle aged; open study; pruritus; sustained virologic response; Taiwanese; treatment duration; treatment response; virus load; antiviral resistance; combination drug therapy; drug effects; genetic polymorphism; genetics; genotype; Hepacivirus; Hepatitis C, Chronic; liver cirrhosis; Taiwan; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Isoquinolines; Liver Cirrhosis; Male; Middle Aged; Polymorphism, Genetic; Ribavirin; Sulfonamides; Taiwan; Viral Load; Viral Nonstructural Proteinsjournal article10.1016/j.jfma.2016.11.014280344922-s2.0-85009179157