臺大醫學院-臨床醫學研究所;Keller, Joseph J.Joseph J.KellerLin, Hsiao-YuHsiao-YuLinChung, Shiu-DongShiu-DongChungLin, Herng-ChingHerng-ChingLin2017-06-222018-07-062017-06-222018-07-062012http://ntur.lib.ntu.edu.tw//handle/246246/279464Introduction. While erectile dysfunction (ED) and cardiovascular disease have long been known to share endothelial dysfunction as a common contributory underlying mechanism, little research has been conducted taking endothelial dysfunction as common ground to investigate the potential association between ED and gastric ulcers (GUs). ;Aim. This population-based case-control study aimed to investigate the association of ED with GU. ;Methods. This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study group comprised 6,906 patients who visited ambulatory care centers or were hospitalized with a diagnosis of ED. The comparison group was 20,718 randomly selected enrollees. Conditional logistic regression was used to examine associations between ED and prior GU. ;Main Outcome Measure. The prevalence and risk between cases and controls were calculated of having been previously diagnosed with GU. ;Results. Of the sampled subjects, 3,861 (14%) were diagnosed before the index date, 1,358 (19.7%) were cases, and 2,503 (12.1%) were controls (P < 0.001). After adjusting for hypertension, diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, alcohol abuse/alcohol dependence syndrome, and socioeconomic status (SES), conditional logistic regression analysis revealed that cases were more likely to have been diagnosed with GU than controls (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.53-1.77). Stratification by age revealed that the youngest group (18-29) of ED patients had the most increased likelihood of having been previously diagnosed with GU when compared with matched controls (OR = 4.12, 95% CI = 2.41-7.03). The likelihood decreased with age, with the oldest group of ED patients having the least increased likelihood of prior GU when compared with matched controls (OR = 1.44, 95% CI = 1.23-1.68). ;Conclusion. Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED. Keller JJ, Lin H-Yu, Chung S-D, and Lin H-C. A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan. J Sex Med 2012; 9: 686-693.Erectile DysfunctionGastric UlcersEpidemiology[SDGs]SDG3adult; aged; alcohol abuse; alcoholism; article; case control study; controlled study; diabetes mellitus; disease association; erectile dysfunction; human; hyperlipidemia; hypertension; ischemic heart disease; kidney disease; longitudinal study; major clinical study; male; obesity; prevalence; priority journal; risk assessment; social status; stomach ulcer; Taiwan10.1111/j.1743-6109.2011.02614.x