戴政臺灣大學：流行病學研究所王雅婷Wang, Ya-TingYa-TingWang2007-11-272018-06-292007-11-272018-06-292004http://ntur.lib.ntu.edu.tw//handle/246246/56226本研究根據最簡單的三元體家庭資料，模擬當只考慮父母之一標識對偶基因為異質基因型的家庭時，在特定疾病基因頻率、標識基因頻率及遺傳模式下，利用TDT統計量求出檢定力。再應B-值統計量可以依目前所收資料推測結果趨勢之特性，估計出若家庭資料收集至預期樣本數時之條件檢定力。最後，將比較TDT統計量所得之檢定力與經由B-值統計量觀念所得條件檢定力之關係。Transmission/disequilibrium test (TDT) is a commonly used method for analysis of linkage. The basis data unit used for TDT method is the case-parent triad family. Since collection of triad families could be sequentially in practical study, it is interesting to develop power-monitoring procedure for TDT testing procedure. In this paper, we use the B-Value statistic to accomplish the goal. The sequential monitoring procedure is illustrated with some examples under various genetic models.中文摘要..................................................I Abstract.................................................II 目錄索引................................................III 表目錄...................................................IV 第一章　緒論..............................................1 第二章　遺傳連鎖分析......................................4 2.1利用相對風險觀念衍生的方法.............................6 2.2 TDT檢定（transmission/disequilibrium test）..........11 第三章　B-Value於臨床試驗的應用..........................13 第四章　TDT與B-Value統計量的結合.........................21 4.1　研究動機............................................21 4.2　TDT統計量與B-Value統計量結合........................22 4.3模擬：舉例............................................24 第五章　討論.............................................27 附錄一　名詞釋義.........................................29 參考文獻.................................................32en-USB-值TDT統計量條件檢定力樣本數conditional powersample sizeTDT statisticB-Valuethesis