Juan, Li TingLi TingJuanLin, Shih HoShih HoLinWong, Chui WeiChui WeiWongJeng, U. SerU. SerJengHuang, Chih FengChih FengHuangSHAN-HUI HSU2023-06-092023-06-092022-08-1719448244https://scholars.lib.ntu.edu.tw/handle/123456789/632010Cellulose nanofibers functionalized with multiple aldehyde group were synthesized as the crosslinker to produce composite self-healing hydrogel and shape memory cryogel from chitosan. The hydrogel possessed effective self-healing (∼100% efficiency) and shear-thinning properties. The cryogel had macroporous structure, large water absorption (>4300%), and high compressibility. Both hydrogel and cryogel were injectable. In particular, the cryogel (nanocellulose/chitosan 1:6) revealed thermally induced shape memory, the mechanism of which was elucidated by in situ small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS) as changes in orientation of the induced crystalline structure during the shape memory program. The shape memory cryogel with a large size (15 mm × 10 mm × 1.1 mm) injected through a 16 G syringe needle was recoverable in 37 °C water. Moreover, the cryogel was cytocompatible and promoted cell growth. The nanocellulose-chitosan composite hydrogel and cryogel are injectable and degradable biomaterials with adjustable mechanical properties for potential medical applications.encellulose nanofiber | chitosan | cryogel | self-healing hydrogel | shape memory[SDGs]SDG6journal article10.1021/acsami.2c07170359307412-s2.0-85135990396WOS:000846885600001https://api.elsevier.com/content/abstract/scopus_id/85135990396