SHIH-CHE WENGPO-NIEN TSAOSHIN-HONG SHIAO2022-02-142022-02-142021-07-261756-3305https://scholars.lib.ntu.edu.tw/handle/123456789/594092Dengue fever is the most rapidly spreading mosquito-borne viral disease globally. More than 2.5 billion people live in dengue-endemic areas. Previous studies suggested an interrelationship between diabetes mellitus (DM) and dengue hemorrhagic fever (DHF). Conversely, glycolysis is a critical metabolic pathway for optimal dengue virus (DENV) replication. However, little is known concerning the effect of glucose on DENV replication in mosquitoes. In this study, we investigated the impact of glucose on DENV replication in mosquitoes Aedes aegypti.enAedes aegypti; Dengue virus; Glucose; Signaling pathway[SDGs]SDG3double stranded RNA; glucose; mammalian target of rapamycin; protein kinase B; viral protein; Aedes aegypti; Akt/mTOR signaling; animal cell; animal experiment; Article; comorbidity; controlled study; dengue; disease transmission; female; gene expression; glucose blood level; mouse; nonhuman; saliva; serotype; upregulation; virus genome; virus load; virus replication; Western blotting; Aedes; animal; dengue; Dengue virus; drug effect; human; mosquito vector; physiology; RNA interference; signal transduction; virology; Aedes; Animals; Blood Glucose; Dengue; Dengue Virus; Female; Humans; Mosquito Vectors; RNA Interference; Serogroup; Signal Transduction; Virus Replicationjournal article10.1186/s13071-021-04877-1343117762-s2.0-85111281891WOS:000680863100002https://scholars.lib.ntu.edu.tw/handle/123456789/577814