Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

YI-HSIN LIANGKUO-HSING CHENJIA-HUEI TSAICheng, Yung-MingYung-MingChengLee, Chang-ChengChang-ChengLeeKao, Chiu-HwaChiu-HwaKaoChan, Kuang-YuKuang-YuChanChen, Yeh-TingYeh-TingChenHsu, Wen-LingWen-LingHsuKUN-HUEI YEH2022-07-112022-07-112021-11-101021-7770https://scholars.lib.ntu.edu.tw/handle/123456789/614778A new strategy, particularly a novel combination, for immunotherapy in microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated. Studies on the interferon-γ (IFN-γ)/ Janus kinase (JAK)/ signal transducer and activator of transcription (STAT)1 pathway provide new directions in this regard.enColorectal cancer; Interferon-γ (IFN-γ); Major histocompatibility complex (MHC) class I; Proteasome inhibitors; STAT1; Tumor infiltrating lymphocytes (TILs)[SDGs]SDG3Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cellsjournal article10.1186/s12929-021-00769-9347588262-s2.0-85118835309WOS:000716925400001https://scholars.lib.ntu.edu.tw/handle/123456789/590978