Padmos R.M.J?zsa T.I.El-Bouri W.K.Z?vodszky G.Payne S.J.Hoekstra A.G.STEPHEN JOHN PAYNE2022-05-242022-05-242021https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111392336&doi=10.1007%2f978-3-030-77967-2_56&partnerID=40&md5=8930670cc8a7a8c2bd743f5aeebf0fechttps://scholars.lib.ntu.edu.tw/handle/123456789/611714Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupling of a one-dimensional arterial blood flow model and a three-dimensional tissue perfusion model. The two-way coupling occurs through the pial surface, where the pressure drop between the models is captured using a coupling resistance. The two-way coupled model is used to simulate arterial blood flow and tissue perfusion during an acute ischaemic stroke. Infarct volume is estimated by setting a threshold on the perfusion change. By two-way coupling these two models, the effect of retrograde flow and its effect on tissue perfusion and infarct volume can be captured. ? 2021, Springer Nature Switzerland AG.BloodHemodynamicsOne dimensionalTissueArterial bloodCoupled modelingCoupling resistanceMultiple scalePerfusion modelsRetrograde flowTissue perfusionTwo-way couplingTissue engineeringconference paper10.1007/978-3-030-77967-2_562-s2.0-85111392336