Shu-Yung LinJIN-SHING CHENMin-Shu HsiehChao-Chi Ho2022-10-142022-10-142014-12-011023-9855AL:10239855-201412-201411210019-201411210019-358-364https://scholars.lib.ntu.edu.tw/handle/123456789/623782Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare pulmonary condition presenting with cough, wheezing, and obstructive ventilatory defect. The pathogenesis of the disease is diffuse hyperplasia or dysplasia of pulmonary neuroendocrine cells, multiple carcinoid tumorlets, and peribronchiolar fibrosis causing small airway obliteration. Herein, we present the case of a 70-year-old patient with this rare condition who had been treated for asthma for years, and who had a left lower lung tumor noted during follow-up chest radiography. Chest computed tomography showed a mosaic pattern of the lung parenchyma and multiple lung nodules. The pathological diagnosis of DIPNECH was made after a surgical resection of the lung nodules. The patient's symptoms remained stable with inhaled corticosteroid and bronchodilator use.endiffuse idiopathic pulmonary neuroendocrine cell hyperplasianeuroendocrine cellstumorletscarcinoidlung neoplasmjournal article