Jun, S.W.S.W.JunKwon, J.J.KwonChun, S.K.S.K.ChunLee, H.A.H.A.LeeLee, J.J.LeeHwang, D.Y.D.Y.HwangCHEN-YUAN DONG2019-12-192019-12-192018https://scholars.lib.ntu.edu.tw/handle/123456789/436272Owing to its near infrared (NIR) absorption, graphene oxide (GO) is promising for both photothermal (PT) therapy and multiphoton (MP) imaging. Novel therapy/imaging modality switching is proposed here based on the selected excitation wavelength of femtosecond (FS) laser. GO-based destruction of cancer cells is demonstrated when the laser power of 800-nm-wavelength FS laser is increased above 7 mW. However, GO-based imaging is mainly monitored without damaging the sample when using 1200-nm wavelength FS laser in the same laser power range. Folic acid (FA) conjugated graphene oxide (FA-GO) was synthesized for selective cancer cell targeting. Dual-function FA-GO-based cancer cell targeting agents were experimentally optimized to enable therapy/imaging modality switching. ? 2018 Optical Society of America.[SDGs]SDG3Cells; Diseases; Graphene; Infrared devices; Multiphoton processes; Organic acids; Cancer cell targeting; Cancer cells; Dual function; Excitation wavelength; Femtosecond (fs) laser; Graphene oxides; Near-infrared absorption; Photo-thermal; Laser excitation; folic acid; graphene oxide; Article; atomic force microscopy; controlled study; fluorescence imaging; human; human cell; infrared spectroscopy; multiphoton microscopy; photothermal therapy; three dimensional imaging; two-dimensional imaging; ultraviolet spectroscopyjournal article10.1364/BOE.9.0007052-s2.0-85041534183https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041534183&doi=10.1364%2fBOE.9.000705&partnerID=40&md5=734592cd04efd2e5f947d26e1274f9c0